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Opportunity at National Institute of Standards and Technology (NIST)

Improving Measurement Assurance of In Vitro Toxicity Assays

Location

Material Measurement Laboratory, Biosystems and Biomaterials Division

RO# Location
50.64.41.C0251 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Elliott, John Timothy jelliott@nist.gov 301.975.8551
Nelson, Bryant C. bryant.nelson@nist.gov 301.975.2517
Petersen, Elijah Joel elijah.petersen@nist.gov 301.975.8142

Description

In vitro and acellular assays can play an important role in determining the potential toxicity of compounds to humans and ecological receptors. To establish the extent of the biological relevance of these assays in predicting the effects in physiological systems, a high-level of confidence in the precision and robustness of these assay measurements is required. This postdoctoral opportunity features an opportunity to comprehensively examine an in vitro assay or assays to improve the repeatability and interlaboratory agreement of the assay results. This could entail using cause-and-effect analysis to understand sources of variability in the assay, designing new plate layouts that include key process control measurements, and utilizing appropriate statistical analyses to understand the assay results and their uncertainties. This process should lead to improvements in the comparability and reproducibility of assay results within and between laboratories.

Keywords:
cell-based assays; measurement science; cytotoxicity; high quality assays; biological reference methods

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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