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Opportunity at National Institute of Standards and Technology (NIST)

Computational Molecular Evolution and Bioinformatics

Location

Material Measurement Laboratory, Biosystems and Biomaterials Division

RO# Location
50.64.41.B8280 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Stoltzfus, Arlin arlin.stoltzfus@nist.gov 240.314.6208

Description

Between the detailed knowledge of macromolecules provided by molecular and structural biology and the rough chronicle of their evolutionary history inferred from phylogenetic analysis lies a huge gap in our understanding of the causal principles at work in the origin of macromolecular structure and function. Our mission is to narrow this gap, with emphasis placed on the poorly understood role of evolutionary factors other than natural selection.

This research utilizes computational and analytical modeling of evolution processes, as well as quantitative analyses of sequence and structure data from genes, proteins, and genomes. Ongoing and planned projects include developing bioinformatics tools to aid in ongoing research, developing and testing hypotheses of the role of mutation biases in evolution, and developing models that address the evolution of molecular novelty.

We welcome projects in any area of molecular evolution or bioinformatics. Past work includes topics as diverse as Bayesian methods for fossil calibration of trees, the evolution of ORFan genes in E. coli, and the evolution of the genetic code. We especially welcome projects related to disseminating phylogenetic knowledge (see http://www.phylotastic.org/), analyzing systematic data on mutational effects from deep mutational scanning studies, and theoretical and empirical approaches to the role of mutation bias in evolution.

 

Keywords:
Bioinformatics; Biomathematics; Computer simulation; Modeling; Molecular evolution;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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