Opportunity at National Institute of Standards and Technology (NIST)
Mathematical Models for Characterizing Pluripotent Stem Cell Populations
Material Measurement Laboratory, Biosystems and Biomaterials Division
Please note: This Agency only participates in the February and August reviews.
The application of stem cell technologies as therapies and diagnostics will depend on effective biomanufacturing strategies that lead to predictable and reproducible cell product. We have shown that fluctuations in promoter activity can be used in combination with appropriate models to predict rates of state change in cell populations. Similar mathematical models that can inform bioprocessing decisions during scale-up will be critical to obtaining cellular populations within defined specifications. The goal of this research project is to evaluate models that could be used to predict the activity of pluripotent stem cell populations, which are often highly heterogeneous and can exhibit complex responses.
Stochastic models; Gene expression; Fluorescence protein reporters; Single cell analysis; Stem cell; Pluripotency; Differentiation; Fluorescence microscopy;
Open to U.S. citizens
Open to Postdoctoral applicants