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Opportunity at National Institute of Standards and Technology (NIST)

Mechanisms of Amorphous Materials Dynamics for Therapeutic Protein Stabilization

Location

Material Measurement Laboratory, Biosystems and Biomaterials Division

RO# Location
50.64.41.B8097 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Cicerone, Marcus T. marcus.cicerone@nist.gov 301.975.8104

Description

Sugar-based glasses have been used for decades to encapsulate and stabilize therapeutic proteins, vaccines, and other biological structures. Although this approach has been used widely in biopharmaceutics and other fields for decades, the fundamental mechanisms by which these glasses stabilize biological structures is not understood. This is perhaps not surprising since glasses in general are not well understood.

We have recently demonstrated an apparently universal correlation between ps dynamic processes in sugar-glass and degradation rates of proteins encapsulated in them. We have further proposed a mechanistic link between these ps dynamics and transport in glassy materials that would connect ps dynamics with protein stability.

These first steps in establishing a fundamental understanding of the protein preservation mechanisms are encouraging, but only schematic at this point. In this research opportunity we use nonlinear optics, neutron scattering, and molecular dynamics simulation to understand the fundamental relationship between local, ps timescale relaxation processes and transport, with an eye towards developing a quantitative relationship between these dynamic processes and degradation rates of proteins and vaccines encapsulated in glassy materials.

 

References

Cicerone MT, Douglas JF: Soft Matter 8: 2983, 2012

Cicerone MT, Zhong Q, Tyagi M: Physical Review Letters 113: 117801, 2014

 

Keywords:
Glass; protein Stability; Biopharmaceutical; Transport; Nonlinear; Optics; Dynamics;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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