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RAP Lab Opportunities at NIST

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Opportunity at National Institute of Standards and Technology (NIST)

Quantitative Nuclear Magnetic Resonance Measurements for Chemical and Biochemical Applications

Location

Material Measurement Laboratory, Biosystems and Biomaterials Division

RO# Location
50.64.41.B7624 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Bearden, Daniel W. dan.bearden@nist.gov 843.762.8865
Choquette, Steven Joseph steven.choquette@nist.gov 301.975.3096
Lippa, Katrice Ann katrice.lippa@nist.gov 301.975.3116
Urbas, Aaron Andrew aaron.urbas@nist.gov 301.975.8791

Description

This research focuses on the development of quantitative nuclear magnetic resonance (qNMR) techniques to improve solution-state measurement capabilities in the areas of environmental and clinical/nutritional science as well as pharmaceuticals and biomanufacturing. An emphasis is on the development of robust quantitative methodologies to accurately determine various levels of biological and chemical analytes in complex liquid-state matrices and to establishing the metrological traceability of such measurement processes. This quantitative NMR research effort can be combined with other supporting analytical techniques (GC-TOFMS, LC-MS/MS, vibrational spectroscopy). Novel quantitative methods for two-dimensional NMR applications (e.g., heteronuclear single quantum correlation [HSQC] methods) as well as chemometric methods for spectral processing may also be of interest. This interdisciplinary work is appropriate to those with expertise in fields such as biology, chemistry, chemical engineering, and materials science, and with expertise in various spectroscopy and analytical separation techniques.

Current facilities include a Bruker 600 MHz NMR spectrometer dedicated to quantitative research at the Gaithersburg MD site, with additional access to Bruker 700 MHz and 800 MHz spectrometers with cryoprobe capability at the Charleston SC NMR facility. In addition, the Charleston SC systems are equipped for use with LC-MS instrumentation for multidimensional measurement processes.

 

Keywords:
Quantitative nuclear magnetic resonance (qNMR); Metrology; Purity; Biomaterials; Chromatography; Mass spectroscopy; Hyphenated methods; LC-NMR/MS; Chemometrics;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Regular applicants
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