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RAP Lab Opportunities at NIST

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Opportunity at National Institute of Standards and Technology (NIST)

Development of Quantitative Gene Expression Profiling for Small Biological Samples


Material Measurement Laboratory, Biosystems and Biomaterials Division

RO# Location
50.64.41.B7607 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.


Name E-mail Phone
Kralj, Jason G jason.kralj@nist.gov 301.975.4130


Global gene expression profiling of small biological samples is a major challenge inhibiting our understanding of the complex interactions that occur between cells and their local microenvironment. While techniques such as laser capture microdissection make it possible to collect minute samples, the amplifications and assays used to analyze the specimens have a high degree of uncertainty associated with them. We seek to characterize this variability and make improvements to the existing processes using a combination of modifications and new technologies (e.g., high throughput sequencing, microarrays, functionalized microbeads, and microfluidics) to enable highly accurate characterization of global gene expression using a biological sample of any size.


Gene expression; Single cell; mRNA; Microfluidics; Bead-based assay;


Citizenship:  Open to U.S. citizens
Level:  Open to Regular applicants
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