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Opportunity at National Institute of Standards and Technology (NIST)

Functional Measurements of Tissue Engineered Retinal Pigment Epithelium

Location

Material Measurement Laboratory, Biosystems and Biomaterials Division

RO# Location
50.64.41.B7298 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Simon, Carl George carl.simon@nist.gov 301.975.8574

Description

We will develop advanced methods for assessing the function of tissue engineered retinal pigment epithelium (RPE). The RPE is a monolayer of cells located in the back of the eye which supports healthy vision by maintaining the photoreceptor cells.  Many vision disorders, such as age-related macular degeneration, are related to poor RPE function, which has stimulated development of regnerative approachesfor repair.  In collaboration with Dr. Kapil Bharti at NIH, we will develop methods to assess the functional attributes of RPE generated from induced pluripotent stem cells (iPSCs).  Methods will include non-invasive/non-destructive methods for assing RPE funciton, methods that are compatible with large scale manufacutring in a GMP-setting and methods to assess variability between manufactured batches of tissue-engineered RPE.   The development of these methods will enable reliable characterization of manufactured RPE.

Keywords:
Biomaterials; Cell differentiation; Ceramics; Combinatorial; Hydrogel; Nanofibers; Polymer; Scaffold; Stem cell; Tissue engineering; Regenerative medicine;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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