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Opportunity at National Institute of Standards and Technology (NIST)

Interface Tissue Engineering with Graded or Stratified 3D Scaffolds

Location

Material Measurement Laboratory, Biosystems and Biomaterials Division

RO# Location
50.64.41.B7297 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Simon, Carl George carl.simon@nist.gov 301.975.8574

Description

We plan to develop methods for generating graded tissues for interface tissue engineering. Gradients are prevalent in biology and gradients in molecules, composition, and properties exist at the interfacial regions of many tissues and organs such as ligaments, tendons, teeth, intestine, and vasculature. During organismal development, morphogen gradients are the primary mechanism used to drive pattern formation and organogenesis. Organs are composed of stratified tissues with gradients from one stratum to the next. Arteries have an intima, media, and adventitia which are populated with endothelial cells, smooth muscle cells, and fibroblasts, respectively. Ligaments transition from soft non-mineralized connective tissue containing fibroblasts into harder mineralized bone tissue containing osteoblasts. Thus, engineering three-dimensional (3D) interface constructs that span multiple cell types and tissues is critical to the success of regenerative medicine. In this project, new techniques for fabricating and characterizing graded or stratified tissues in 3D will be developed. Methods for assessing stem cell differentiation, tissue development, tissue properties, and co-culture of multiple tissues in graded/stratified scaffolds will be explored.

 

Keywords:
Biomaterials; Cell differentiation; Combinatorial; Electrospinning; Hydrogel; Nanofibers; Polymers; Scaffold; Stem cell; Tissue Engineering; Regenerative medicine;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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