Opportunity at National Institute of Standards and Technology (NIST)
Interface Tissue Engineering with Graded or Stratified 3D Scaffolds
Material Measurement Laboratory, Biosystems and Biomaterials Division
Please note: This Agency only participates in the February and August reviews.
|Simon, Carl George
We plan to develop methods for generating graded tissues for interface tissue engineering. Gradients are prevalent in biology and gradients in molecules, composition, and properties exist at the interfacial regions of many tissues and organs such as ligaments, tendons, teeth, intestine, and vasculature. During organismal development, morphogen gradients are the primary mechanism used to drive pattern formation and organogenesis. Organs are composed of stratified tissues with gradients from one stratum to the next. Arteries have an intima, media, and adventitia which are populated with endothelial cells, smooth muscle cells, and fibroblasts, respectively. Ligaments transition from soft non-mineralized connective tissue containing fibroblasts into harder mineralized bone tissue containing osteoblasts. Thus, engineering three-dimensional (3D) interface constructs that span multiple cell types and tissues is critical to the success of regenerative medicine. In this project, new techniques for fabricating and characterizing graded or stratified tissues in 3D will be developed. Methods for assessing stem cell differentiation, tissue development, tissue properties, and co-culture of multiple tissues in graded/stratified scaffolds will be explored.
Biomaterials; Cell differentiation; Combinatorial; Electrospinning; Hydrogel; Nanofibers; Polymers; Scaffold; Stem cell; Tissue Engineering; Regenerative medicine;
Open to U.S. citizens
Open to Postdoctoral applicants