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RAP Lab Opportunities at NIST

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Opportunity at National Institute of Standards and Technology (NIST)

Isolating and Culturing Rare Circulating Tumor Cells

Location

Material Measurement Laboratory, Biosystems and Biomaterials Division

RO# Location
50.64.41.B7207 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Forry, Samuel P. sam.forry@nist.gov 301.975.5246
Kralj, Jason G jason.kralj@nist.gov 301.975.4130
Munson, Matthew S matt.munson@nist.gov 650.690.6761
Ross, David J. david.ross@nist.gov 301.975.2525
Salit, Marc L. msalit@nist.gov 650.350.2338

Description

We are developing strategies to isolate and capture rare circulating tumor cells (CTC) from raw biological samples (e.g., whole blood) in a viable state, permitting re-culturing and analysis. The ability to isolate and manipulate these rare cells is a unique opportunity to observe and study cancer metastasis and its mechanisms. The project will focus on design and fabrication of devices with the potential to screen large-volume blood samples for CTCs; exploring surface functionalization and material selection for optimal capture, collecting and reculturing cells, and characterizing the cells with molecular and cellular imaging approaches such as next generation sequencing and fluorescence microscopy.

 

Keywords:
Cell sorting; Circulating tumor cells; High throughput sequencing; Microfluidics; Molecular biology; Next generation sequencing; Whole blood assays ;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Regular applicants
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