With this research, we will address critical issues in the methodology for evaluating nanoparticle toxicity using in-vitro models of biological systems. Recently, it has been demonstrated that changes in the microenvironment of cultured cells can lead to dramatic changes in cell response, especially if the cells are exposed to nanoparticle-type external agents. Additionally, the geometry and composition of nanoparticles, as well as their position inside cells are key parameters in their potential toxicity.
Projects that we are interested in investigating include, but are not limited to, microfluidic approaches to separate, sort, position and utilize nanoparticles; nanowires and carbon nanotubes; combinatorial experiments with diverse types of nanoparticles to study nanotoxicity in cells; and development of novel microfluidic approaches to better mimic biological systems and simulate their response to nanotoxic agents.
Since this research is highly interdisciplinary, we are seeking applicants from many diverse fields including chemistry, materials science, electrical engineering, mechanical engineering, biomedical engineering, chemical engineering, physics, and biology.
Cellular models; Combinatorial analysis; In vitro analysis; Microfluidics; Nanomaterials and nanoparticles; Nanotoxicity;