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RAP Lab Opportunities at NIST

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Opportunity at National Institute of Standards and Technology (NIST)

Lab-on-a-Chip Technologies for Nanotoxicity Studies in Biosystems

Location

Material Measurement Laboratory, Biosystems and Biomaterials Division

RO# Location
50.64.41.B7084 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Nelson, Bryant C. bryant.nelson@nist.gov 301.975.2517

Description

With this research, we will address critical issues in the methodology for evaluating nanoparticle toxicity using in-vitro models of biological systems. Recently, it has been demonstrated that changes in the microenvironment of cultured cells can lead to dramatic changes in cell response, especially if the cells are exposed to nanoparticle-type external agents. Additionally, the geometry and composition of nanoparticles, as well as their position inside cells are key parameters in their potential toxicity.

Projects that we are interested in investigating include, but are not limited to, microfluidic approaches to separate, sort, position and utilize nanoparticles; nanowires and carbon nanotubes; combinatorial experiments with diverse types of nanoparticles to study nanotoxicity in cells; and development of novel microfluidic approaches to better mimic biological systems and simulate their response to nanotoxic agents.

Since this research is highly interdisciplinary, we are seeking applicants from many diverse fields including chemistry, materials science, electrical engineering, mechanical engineering, biomedical engineering, chemical engineering, physics, and biology.

 

Keywords:
Cellular models; Combinatorial analysis; In vitro analysis; Microfluidics; Nanomaterials and nanoparticles; Nanotoxicity;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Regular applicants
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