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RAP Lab Opportunities at NIST

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Opportunity at National Institute of Standards and Technology (NIST)

Cellular Biometrology: Microfluidic Integration of Cell Culture and Analysis

Location

Material Measurement Laboratory, Biosystems and Biomaterials Division

RO# Location
50.64.41.B6975 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Cooksey, Gregory Alan gregory.cooksey@nist.gov 301.975.5529
Elliott, John Timothy jelliott@nist.gov 301.975.8551
Forry, Samuel P. sam.forry@nist.gov 301.975.5246
Kralj, Jason G jason.kralj@nist.gov 301.975.4130
Munson, Matthew S matt.munson@nist.gov 650.690.6761
Plant, Anne L. anne.plant@nist.gov 301.975.3124
Ross, David J. david.ross@nist.gov 301.975.2525

Description

The NIST Cellular Biometrology project includes two main thrusts: the development of cell culture capabilities in a microfluidic format and the integration of quantitative cellular analysis in the same platform. Microfluidics promise to revolutionize cell culture by providing exquisite control over the cellular microenvironment, including generation of spatial and temporal concentration gradients of soluble factors and dissolved gases (e.g., O2, and CO2) in a multiplexed fashion, allowing efficient assessment of a wide parameter space. Microfluidics can facilitate investigations of small samples, including individual cells and heterogeneous cell populations. Additionally, parallel analysis of different classes of biomolecules from the same cell(s) is of great interest to enable simultaneous genomics, proteomics, and metabolomics studies for application to systems biology, cellular differentiation, and cytotoxicty.

 

Keywords:
BioMems; Cell-based assay; Cytotoxicity; Microfluidic; Multiplexed measurements; Nanoparticle; Proteomics; Quantitative cell biology; Systems biology;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Regular applicants
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