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RAP Lab Opportunities at NIST

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Opportunity at National Institute of Standards and Technology (NIST)

Screening Osteoblast Response to Calcium Phosphate Composite Tissue Scaffolds

Location

Material Measurement Laboratory, Biosystems and Biomaterials Division

RO# Location
50.64.41.B6517 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Lin, Nancy J nancy.lin@nist.gov 301.975.4935
Simon, Carl George carl.simon@nist.gov 301.975.8574

Description

We will develop methods to explore cell response to multiphase tissue scaffolds that mimic natural bone through inclusion of a calcium phosphate phase. Calcium phosphate is the main component of the mineral phase of bone, and osteoblasts in vivo generate new bone in tight apposition to calcium phosphate implants. Polymeric scaffolds containing a calcium phosphate ceramic phase such as hydroxyapatite, tricalcium phosphates, amorphous calcium phosphate, or hydroxyapatite nanoparticles will be fabricated. Osteoblasts will be cultured in the scaffolds and the ability of the multiphase materials to support bone generation will be evaluated. Methods for fabricating scaffolds in the forms of arrays or gradients will be pursued to yield new methodologies for screening osteoblast performance in multiphase tissue scaffolds. Mechanisms of action will be explored including release of Ca and P ions, protein adsorption/conformation, changes in calcium phosphate crystallinity, and effects of surface chemistry and topology.

Keywords:
Cell biology; Composites; Polymers; Tissue scaffolds; Osteoblast; Bone; Tissue engineering; Regenerative medicine;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Regular applicants
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