Bioactive polymers and composites with the mineralizing potential may arrest and/or reverse tooth decay and bone loss. We are developing methods and related materials to measure the mechanisms and kinetics of demineralization/remineralization processes in order to facilitate development of these classes of materials. The methods must capture reliable, time-dependent chemical and physical characteristics of the mineralization process. New measurements may include spectroscopy, imaging, or scattering based techniques. New and controlled biomimetic materials with bone- and tooth-like properties are needed to serve as model systems for the advancement of the methods. Improved measurement approaches for direct observation of mineralization kinetics and mechanisms can significantly increase new knowledge relating chemical structure of materials and biological response.
Biomaterials; Biomimetics; Biomineralization; Demineralization; Calcium phosphate;