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RAP Lab Opportunities at NIST

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Opportunity at National Institute of Standards and Technology (NIST)

In Vitro Biomineralization of Calcium Phosphate

Location

Material Measurement Laboratory, Biosystems and Biomaterials Division

RO# Location
50.64.41.B6150 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Lin, Nancy J nancy.lin@nist.gov 301.975.4935
Lin-Gibson, Sheng slgibson@nist.gov 301.975.6765

Description

This program aims to design and synthesize biomimetic materials that replicate the hierarchical, complex nature of mineralized tissues (bone, dentin, and enamel). Recent research efforts have led to new mechanistic insights into calcium phosphate biomineralization. A revolutionary understanding of the pathways governing calcium phosphate nucleation and growth has taken root, resulting in what is described as “non-classical” mineralization. Fundamental to this new model is the importance of prenucleation clusters (stable ion clusters) and reactive amorphous phases in building structured and organized biominerals. This new physicochemical insight paired with extensive work probing the self-organization/mineral interactions of soluble proteins (e.g., amelogenin, dentin sialoprotein) and matrix proteins (e.g., collagen) are producing an improved understanding of biologically generated inorganic structures. This research opportunity will develop measurement methods to gain additional insights into biomineralization processes and/or capitalize on new knowledge to develop biomimetic materials with increasing levels of control and hierarchical structures.

 

Keywords:
Amorphous calcium phosphate; Biomimetics; Biomineralization; Peptides;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Regular applicants
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