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RAP Lab Opportunities at NIST

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Opportunity at National Institute of Standards and Technology (NIST)

Cell-Biomaterials Interactions in Tissue Engineering

Location

Material Measurement Laboratory, Biosystems and Biomaterials Division

RO# Location
50.64.41.B5008 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Cicerone, Marcus T. marcus.cicerone@nist.gov 301.975.8104
Lin, Nancy J nancy.lin@nist.gov 301.975.4935
Lin-Gibson, Sheng slgibson@nist.gov 301.975.6765

Description

Engineering of tissues in vivo and in vitro requires biomaterials that function as scaffolds to guide the organization, growth, and differentiation of cells into functional tissue. While adaptation of existing materials has fulfilled some needs in the field, most applications demand better control of bulk and surface properties to provide the appropriate mechanical, chemical, and biological cues. Knowledge of the precise biomolecular interactions to be initiated or modulated can lead to optimal performance of a device, recruitment, and anchorage of cells onto implant surfaces, and promote differentiation into the desired cell type (e.g., mineralized bone). In this program, interactions of cells with substrates, including mineralized tissues (e.g., teeth and bones), biopolymers, and other biomaterials are investigated. Issues for investigation include interactions between cell surface receptors and ligands on adsorbed macromolecules, molecular rearrangements in adsorbed macromolecules and/or at the cell surface, effects of substrates on accessibility of ligands, and displacement of adsorbed macromolecules by cells. Surface modification methods will be used to control surface characteristics. Molecular biology methods and other bioassays will be used to measure the cellular response. Experimentation will also include fine-tuning the mix of cells and growth factors on films and/or scaffolds to ultimately kick-start and control downstream signaling of biological pathways.;

 

Keywords:
Biochemistry; Bone; Cell biology; Polymers; Receptors (biochemical); Tissue engineering; Ligands; Biomolecular interactions; Surface modification; Biomaterials; Cells; Scaffolds; Mineralization;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Regular applicants
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