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Opportunity at National Institute of Standards and Technology (NIST)

Design and Creation of Nano-scale Surface Functionalized Study Materials for Nanomedicinal Applications

Location

Material Measurement Laboratory, Materials Measurement Science Division

RO# Location
50.64.31.C0431 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Cho, Tae Joon taejoon.cho@nist.gov 301.975.5736

Description

Nano-scale materials have attracted much recent interest for improving bioavailability toward drug delivery carriers, diagnosis/labeling agents, and genome editing tools, etc., to vary their applicability in nanomedicine area. Several critical parameters which should be considered (but generally are not) in the design and creation of bioavailable nanomaterials include solubility, colloidal/physico-chemical stability, surface functionality/charge, and reproducibility. Successful candidates for this research opportunity will focus on the development of nanomaterials with different kinds of core compositions and surface functionalities for nanomedical research. These nano-scale materials are expected to be used as study materials for insightful investigation on colloidal behaviors in various physical /chemical/ physiological conditions.  A suite of orthogonal measurement systems, including DLS, UV-Vis, A4F, ATR-FTIR, ICP-MS, ESI-DMA, TEM, AFM, and XPS, will be available to characterize the prepared materials’ physico-chemical properties as well as their colloidal and physiological stability. The intrinsic toxicity of the prepared nano-scale study materials will also be evaluated for diversity of their utilization (e.g., drug carrier or positive controls). In addition, the project involves the application of drug molecules to specific targets and development of nano-drugs by conjugation between selected nano-scale study materials and disclosed drug moieties. This project may involve collaboration with internal and/or external NIST (industry, government agencies, academia, etc.).

Cho, T. J.; Gorham, J. M; Pettibone, J. M.; Liu, J.; Tan, J.; Hackley, V. A. “Parallel multi-parameter study of PEI-functionalized gold nanoparticle synthesis for bio-medical applications: part 1—a critical assessment of methodology, properties, and stability” J. Nanoparticle Res., 21:188, 2019

 Tan, J.; Cho, T. J.; Tsai, D.-H.; Liu, J.; Pettibone, J. M.; You, R.; Hackley, V. A.; Zachariah, M. R. “Surface Modification of Cisplatin-Complexed Gold Nanoparticles and Its Influence on Colloidal Stability, Drug Loading, and Drug Release” Langmuir, 34, 154, 2018

Keywords:
nanomedicine; synthesis; chemical reactions; surface functionalization; nanomaterials; drug carrier; polymers; dendron/dendrimers; biomaterials; colloidal stability

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants

Stipend

Base Stipend Travel Allotment Supplementation
$72,030.00 $3,000.00
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