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Opportunity at National Institute of Standards and Technology (NIST)

Advanced Regulatory Science for Nanotechnology

Location

Material Measurement Laboratory, Materials Measurement Science Division

RO# Location
50.64.31.C0043 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Gorham, Justin M. justin.gorham@nist.gov 301.975.5944
Hackley, Vincent A. vince.hackley@nist.gov 301.975.5790
Pettibone, John Michael john.pettibone@nist.gov 301.975.5656

Description

This Research Opportunity addresses the needs of regulatory science for nanotechnology based products, including therapeutics, biomedical devices, coatings, food-related materials, and personal care. Work emphasizes the development of analytical methods for quantitative measurement of engineered nanoparticle properties, including bulk and surface composition, surface reactivity, stability, physical state and functional performance (nano-analytics). Research focuses on (1) the development of measurement methods and instrumentation to determine molecular adsorption onto nanoparticles, nanoparticle corona composition, surface density, and conformation of ligands; (2) the differentiation between multiple functional ligands co-conjugated to the nanoparticle surface and to assess the effect of surface coatings on nanoparticle stability and functionality; (3) the development of hyphenated techniques that combine separation with multiple detection modes for size-resolved analysis of nanoparticle core and surface composition; (4) the development of analytical methods for detection and monitoring of engineered nanoparticles and their transformational products in biological systems, including use of stable isotopes combined with mass spectrometry; (5) the development of methods for separation by size/shape/aspect ratio/chemistry; and (6) the development of surface probe techniques to measure properties of nanoparticle coatings.

 

Keywords:
Nanolytics; Metrology; Nanotube; Nanorod; Nanomaterial; Nanoparticle; Nanotechnology; Surface chemistry; Physicochemical properties; Surface functionalization; Measurement; Adsorption; Ligand; Corona; Environment; Hyphenated; Mass spectrometry; Field flow fractionation; Surface probe;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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