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Opportunity at National Institute of Standards and Technology (NIST)

Protein Aggregation

Location

Material Measurement Laboratory, Materials Science and Engineering Division

RO# Location
50.64.21.C0328 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Hudson, Steven David steven.hudson@nist.gov 301.975.6579

Description

Microscopic fluid dynamics at surfaces lead to irreversible protein aggregation; this is a concern for biomanufacturing. Controlling temperature, interface chemistry and shear rate will help decouple the interplay between thermodynamics, interfacial adsorption, and hydrodynamic deformation and transport during the kinetics of protein aggregation. In-situ measurements of adsorption (structure and amount) and particle characterization will determine formation mechanisms.

Keywords:
Protein solutions; Monoclonal antibodies; Interfacial adsorption; Optical microscopy; Microfluidics; Neutron scattering;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants

Stipend

Base Stipend Travel Allotment Supplementation
$72,028.00 $3,000.00
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