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Opportunity at National Institute of Standards and Technology (NIST)

Fate of Nanoparticles in Biosystems

Location

Material Measurement Laboratory, Materials Science and Engineering Division

RO# Location
50.64.21.B6508 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Cicerone, Marcus T. marcus.cicerone@nist.gov 301.975.8104
Prabhu, Vivek M. vprabhu@nist.gov 301.975.3657

Description

This research will address critical issues related to the complete cycle of nanoparticles within biosystems. To predict how readily nanoparticles may enter biological tissues requires an unambiguous knowledge of particle dimensions and surface functionality. We will develop dimensional metrology to obtain precise structural information on nanoparticles combined with image enhancing simulations, and we will develop surface chemical characterization methods with atomic resolution. To reliably predict the state of nanoparticles inside biological tissues requires detailed knowledge of their dispersion and aggregation properties in biological fluids, for which we will develop x-ray scattering and associated metrologies. To estimate the probability of retention and removal of nanoparticles from biosystems requires knowledge of chemical interactions and transport properties of nanoparticles within and across biological tissues. We will develop nanometer-resolution neutron reflection for differentiating nanoparticle diffusion across biomembranes and simulated tissues. Modeling and simulation will generalize the fundamental properties of nanoparticles in biosystems. Through this effort, we will deliver critical support to other agencies such as NIH and EPA engaged in determining toxicology effects of nanoparticles in living organisms.

 

Keywords:
Nanoparticle interactions; Nanoparticle metrology; Nanoparticle toxicology; Nanoparticle transport; Nanoparticles fate; Nanoparticles in biosystems;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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