Opportunity at Armed Forces Radiobiology Research Institute (AFRRI)
Mechanisms of Radiation-Induced Mammalian Cell Injury and Development of Radiation Biomarkers
Armed Forces Radiobiology Research Institute
||Bethesda, MD 208895603
A long-term goal of our group is to understand the role of signal transduction pathways in regulating mammalian cell survival and death after ionizing radiation (IR) and to identify radiation biomarkers that can be used as accurate radiation dose-assessment and to evaluate the effects of radiation countermeasures. It has been suggested that radiation causes cellular DNA damage leading to “danger signals” and antigen release which induce inflammatory and immune reactions. In addition, tissue injury appears to be one pathological state that leads to differential expression of specific microRNAs (miRNAs) and proinflammatory factors in blood. We have a special interest in understanding the effects of low and lethal doses of radiation on cell damage and organ injury. In this project, we will examine our hypothesis that the elevated level of miRNAs and proinflammatory cytokines in mouse tissue and serum after radiation proportionally reflect the severity of radiation-induced tissue damage and can be used as potential biomarkers of radiation injury. The mechanisms by which radiation-induced proinflammatory cytokines and miRNAs release will be investigated. We expected that the results from this study will contribute to develop novel biomarkers which allow rapid evaluation of radiation injury and efficacy of radiation countermeasures as well as triage and prompt medical decisions in the event of a radiological/nuclear incident.
Xiao M. et al.: Urine Interleukin-18 (IL-18) as a Biomarker of Total-Body Radiation Exposure: a Preliminary Study in Nonhuman Primates. Radiation Research. 188:325-334, 2017.
Xiao M. et al.: The Role of Proinflammatory Cytokine Interleukin-18 in Radiation Injury. Health Phys. 111:212-7, 2016.
Li XH. et al.: MicroRNA-30 inhibits antiapoptotic factor Mcl-1 in mouse and human hematopoietic cells after radiation exposure. Apoptosis. 21:708-20, 2016.
Li XH. et al.: Delta-tocotrienol suppresses radiation-induced microRNA-30 and protects mice and human CD34+ cells from radiation injury. PLoS One. 2015 Mar 27; 10(3):e0122258.
ionizing radiation, radiation biomarker, microRNA, inflammatory factors, Signal transduction.
Open to U.S. citizens
Open to Postdoctoral and Senior applicants