Opportunity at Armed Forces Radiobiology Research Institute (AFRRI)
Mechanisms of Non-targeted Effects of Radiation or Depleted Uranium Late Effects
Armed Forces Radiobiology Research Institute
||Bethesda, MD 208895603
|Miller, Alexandra C.
Well-established radiation dogma has been that the biological effects (i.e., cancer) of ionizing radiation occur in irradiated cells as a consequence of the DNA damage they incur. However, many observations of so-called, non-targeted effects indicate that genetic alterations are not restricted to directly irradiated cells. Non-targeted effects are responses exhibited by non-irradiated cells that are the descendants of irradiated cells (radiation-induced genomic instability) or by cells that have communicated with irradiated cells (radiation-induced bystander effects). Radiation-induced genomic instability is characterized by chromosomal abnormalities, gene mutations, and cell death. Similar effects, as well as responses that may be regarded as protective, have been attributed to bystander mechanisms. To date, the majority of studies have used in vitro systems but some non-targeted effects have been demonstrated in vivo and there is also evidence for radiation-induced instability in the mammalian germ line. The goal of our studies is to determine if non-targeted radiation effects are involved in the development of radiation- or depleted uranium-induced late effects including leukemia and transgenerational effects in offspring. Non-targeted mechanisms have significant implications for understanding mechanisms of radiation action but the current state of knowledge does not permit definitive statements about whether these phenomena have implications for assessing radiation risk. A further goal is to evaluate whether epigenetic or genetic mechanisms are associated with radiation late effects like leukemia or transgenerational carcinogenesis.
Non-targeted radiation effects; Mechanism; Radiation; Depleted uranium; Leukemia; Transgenerational; Offspring;
Open to U.S. citizens
Open to Postdoctoral and Senior applicants