Opportunity at U.S. Army Research Office (ARO)
Investigating Normal Physiology and Blast-induced Damage of Hair Cells in a Mature Cochlea
US Army Research Office-Imperial College London, Dept of Bioengineering and Centre for Blast Injury Studies, London, UK
||London, ENGLAND, U.K.
|Gregory, Frederick Deshawn
An opportunity is available to work in the auditory neurophysiology laboratory of Dr. Andriy Kozlov at Imperial College London. The exquisite sensitivity of apical bundles from auditory hair cells makes them susceptible to mechanical trauma. Extreme mechanical loading from explosive blasts can irreversibly damage hair cells leading to a variety of auditory dysfunction in humans. This effort is focused on investigating structural and functional impacts of isolated primary blast on the tonotopic and apical-basal organization of hair cell mechanotransduction and afferent/efferent signaling proteins in the mature rat cochlea. Our group is affiliated with the Centre for Blast Injury Studies and has access to a shock-tube blast generator. The lab is focused on biophysical characterization of shockwave-induced damage to the auditory pathway and uncovering fundamental mechanisms of mechanotransduction and afferent/efferent transmission that support the early stages of auditory processing. We center on an integrated approach that employs whole-cell electrophysiology and immuno-histopathological characterization from whole-mount preparations of the adult mammalian cochlea. Expertise in one of these areas is required.
Gianoli F., Risler T. & Kozlov A. S. (2017) Lipid bilayer mediates ion channel cooperativity in a model of hair-cell mechanotransduction. PNAS 114(51):E11010-E11019.
Kozlov A. S. & Gentner T. (2016) Central auditory neurons have composite receptive fields. PNAS 113(5): 1441-6.
Kozlov A. S., Andor-Ardo D. & Hudspeth A. J. (2012) Anomalous Brownian motion discloses viscoelasticity in the ear's mechanoelectrical-transduction apparatus. PNAS 109(8): 2896-901.
auditory; cochlea; blast; immunostaining; electrophysiology; mechanotransduction; synapses
Open to U.S. citizens, permanent residents and non-U.S. citizens
Open to Postdoctoral and Senior applicants