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Opportunity at Air Force Research Laboratory (AFRL)

Ultrafast Spectroscopic Investigations on the Mechanisms of Interaction of Modified Sensing Proteins with the Electromagnetic Spectrum

Location

711 Human Performance Wing, RHD/Bioeffects Division

RO# Location
13.15.10.B8434 Fort Sam Houston, TX 78234

Advisers

Name E-mail Phone
Schmidt, Morgan Steele morgan.schmidt.1@us.af.mil 210.539.8320

Description

The main objective of this research is to study the effect of directed energy on biological material and determine the resulting impact. To support this mission, this opportunity includes the development of new ultrafast spectroscopic techniques for the investigation of protein interaction with a range of the electromagnetic spectrum (EM). Specifically, we are interested in the use of non-traditional EM frequencies (NIR, IR, RF) in order to move towards a non-invasive optogenetic approach. Our group collaborates with various AFRL laboratories to focus on both the molecular mechanisms, as well as whole cell models, for the development of new, protein-based sensing elements. Molecular simulations, coupled with ultrafast spectroscopic techniques, will be performed in order to validate the engineered proteins as well as provide novel capabilities to AFRL. The laboratory offers extensive laser facilities that operate in the VIS-IR range, as well as MHz-GHz frequency sources. Selected candidates should expect to help design and build optical experiments, collect and analyze complex spectral data, and collaborate with AFRL staff. Understanding of empirical MD simulations and density functional theory (DFT), time-dependent DFT (TDDFT), as well as quantum calculations is also desired.

 

Keywords:
Spectroscopy; Physical chemistry; Chemistry; Molecular dynamics; Biochemistry; Protein dynamics; Optics; Nanoparticles; Optogenetics;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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