The National Academies Logo
Research Associateship Programs
Fellowships Office
Policy and Global Affairs

Participating Agencies - AFRL

  Sign InPrintable View

Opportunity at Air Force Research Laboratory (AFRL)

Investigation of Biological Response to Electromagnetic Exposure

Location

711 Human Performance Wing, RHD/Bioeffects Division

RO# Location
13.15.10.B8076 Fort Sam Houston, TX 78234

Advisers

Name E-mail Phone
Beier, Hope T hope.beier.1@us.af.mil 210.539.8199

Description

Understanding the mechanism(s) underlying the interaction of electromagnetic (laser, thermal, short-pulse electric) energies with biological systems is integral for development of novel technologies provided by interfacing these energies with biology. We aim to understand the electromagnetic exposure biophysics effects at the cellular and sub-cellular component levels, and how this interaction can drive changes in cellular physiology. We are particularly interested in the mechanism(s) underlying infrared (IR) stimulation of neuronal action potentials and the possibility that thermodynamic effects (thermal, pressure, electrical) can increase the probability for spontaneous formation of aqueous channels in the lipid plasma membrane. These channels may allow the influx of ions into the cytosol to initiate the observed cellular effects.

This project focuses on understanding the subtle impacts of electromagnetic energy on cells, with a particular focus on the plasma membrane. Depending on the interests of the researcher, advanced optical imaging techniques such as coherent Raman scattering, high-speed imaging, STED, or confocal or multi-photon microscopy may be used to observe the effects on cells from neuron stimulation by electromagnetic sources. Additionally, wave propagation in neurons may be explored with laser trapping and fluorescence correlation. Applicatns with expertise in neuroscience seeking to expand their techniques repertoire by combining optical approaches with single cell events, such as patch clamp for investigation of their observed cell response phenomenon, are particularly desired, as well as those individuals with demonstrated experience with novel optical sensing and imaging applications.

 

References

Moen E, Ibey BL, Beier HT: Biophysical Journal 106: L37-L40, 2014

Beier HT, et al: Biophysical Research Communications 423(4): 863, 2012

 

Keywords:
Electromagnetic interaction with biology; Plasma membrane; Neuron; Microscopy; Electrophysiology; Action potential; Nanoporation; Neuronal ion channels; STED;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
Copyright © 2014. National Academy of Sciences. All rights reserved. 500 Fifth St. N.W., Washington, D.C. 20001.
Terms of Use and Privacy Statement.