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Opportunity at U.S. Army Edgewood Chemical Biological Center (ECBC)

Applied Aerosol Research

Location

Edgewood Chemical Biological Center, Physical Sciences

RO# Location
11.01.07.B0050 Aberdeen Proving Ground, MD 210105423

Advisers

Name E-mail Phone
Carpin, John Charles john.c.carpin.civ@mail.mil 410.436.3762

Description

Research opportunities are available on the generation and characterization of aerosols for diverse applications of military and nonmilitary interest including drug delivery, toxicological testing, filter media testing, biodetection, and other areas of basic aerosol research. We have emphasized the generation of novel materials such as immunoglobulins and other large molecular weight proteins, which can be damaged when subjected to the mechanical stresses associated with aerosolization. Enzyme linked immunosorbent assay and enzyme kinetics have been used to assess such damage. We have successfully used a prototype magnetic aerosol separator, which was developed in our laboratory, to separate particles from a sample airstream on the basis of their magnetic susceptibility. This device has also been used to study coagulation in mixed aerosol systems composed of paramagnetic and nonmagnetic particles. Specialized instrumentation, such as the electrostatic classifier (TSI model 3071) and the vibrating orifice generator (TSI model 3450), are available for the generation of monodisperse aerosols over a wide range of particle sizes. These instruments are being used to assess the aerosol penetration characteristics of newly developed passive electrostatic filter media. Several small-scale inhalation exposure systems have been developed to assess the efficacy and toxicity of bioactive materials of medical and military interest. In addition, in situ characterization of aerosol delivery systems can be accomplished with available forward scatter (Insitec PCSV-P) and laser diffraction (Malvern 2600c) systems.

 

Keywords:
Aerosols; Filters; Inhalation toxicology; Immunoglobulin; Proteins;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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