The National Academies Logo
Research Associateship Programs
Fellowships Office
Policy and Global Affairs

Participating Agencies - ECBC

  Sign InPrintable View

Opportunity at U.S. Army Edgewood Chemical Biological Center (ECBC)

Elucidation of Virulence Mechanisms and Detection of Pathogens

Location

Edgewood Chemical Biological Center, Life Sciences, Medical Sciences, & Behavioral Sciences

RO# Location
11.01.04.B4623 Aberdeen Proving Ground, MD 210105423

Advisers

Name E-mail Phone
Emanuel, Peter A. peter.a.emanuel.civ@mail.mil 410.436.5562

Description

Pathogen detection by immunoassay gives the biodefense community an established method for assaying environmental samples. However, this technology has limitations that necessitate the development of additional identification methodologies. Detection by polymerase chain reaction (PCR) amplification of nucleic acids offers an additional level of detection that will increase the capability to differentiate between closely related threats and will augment existing technology for even greater confidence in the identification of biowarfare targets. Real-time PCR detection technologies still have several hurdles that must be overcome before this technology can be fielded to support the military. Research interests include but are not limited to mechanisms of invasion, secretory pathways, micro-RNA characterization, and protein and genetic markers of exposure. Research programs exist for developing new PCR assays for detection of pathogens, lyophilization of completed assays, field testing of assay technology, and the utilization of these assays to elucidate virulence mechanisms.

 

Keywords:
Polymerase chain reaction; Biodetection; Virulence; Pathogen; Taqman;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
Copyright © 2014. National Academy of Sciences. All rights reserved. 500 Fifth St. N.W., Washington, D.C. 20001.
Terms of Use and Privacy Statement.