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Opportunity at U.S. Army CCDC Chemical Biological Center (CCDC CBC)

Electrophysiological Characterization of Ion Channel Modulating Substances

Location

U.S. Army CCDC - Chemical Biological Center, Chemistry & Chemical Technology

RO# Location
11.01.01.C0274 Aberdeen Proving Ground, MD 210105423

Advisers

Name E-mail Phone
Glover, Kyle Philip kyle.p.glover.civ@mail.mil 410.417.0298

Description

Automated whole cell patch clamping has allowed for the rapid and repeatable study of individual ion channels for drug developers and drug safety in the pharmacological industry. There is great potential for direct application of these methodologies to emerging threat compound(s) risk assessment. The objective of this research opportunity is to create or adapt methodologies currently in use by Pharma and other drug development pipelines, and optimize these methods for rapid toxicological assessment of chemical warfare agents and threat compounds. A successful proposal will incorporate expertise of electrophysiology, manual or automated, to accomplish the task of characterizing the effects of threat agents on ion channel receptor targets, be it through agonism, antagonism, or direct/indirect modulation.

Keywords:
Electrophysiology; Ion Channels; Toxicity; Patch clamp;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral and Senior applicants

Stipend

Base Stipend Travel Allotment Supplementation
$71,201.00 $3,000.00

$5,000 Supplement for Doctorates in Engineering & Computer Science

$4,050 Supplement for each year of experience in the DTRA CBD-funded NRC tenure at CCDC.

Experience Supplement:
Postdoctoral and Senior Associates will receive an appropriately higher stipend based on the number of years of experience past their PhD.

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