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Opportunity at Chemical and Biological Defense Funded Laboratories (CBD)

Neurotoxicity Assessment of Chemical Warfare Agents and Traumatic Stress: Evaluation of Countermeasures

Location

AMRMC-U.S. Army Medical Research Institute of Chemical Defense, Comparative Medicine Division

RO# Location
01.12.01.B7179 Aberdeen Proving Ground, MD 210105425

Advisers

Name E-mail Phone
Lumley, Lucille Ann lucille.a.lange.civ@mail.mil 410.436.1443

Description

Research efforts focus on (1) the characterization of toxicity of chemical warfare nerve agents and on identification of improved therapeutics against chemical warfare agent exposure and (2) characterization of animal models of post-traumatic stress disorder. In vivo studies are performed in rodents, using endpoints of behavior, physiology, biochemistry, and neuroanatomy to evaluate efficacy of candidate pretreatments and therapeutics against nerve agent-induced toxicity, and to characterize social stress models. Classes of compounds being evaluated for efficacy against nerve agent exposure include, but are not limited to steroid hormones, neuropeptides, antiglutamatergics, and anticholinergics. We are (1) performing risk assessment studies, (2) evaluating prophylactics and therapeutics for efficacy against toxic levels of nerve agent, (3) evaluating mechanisms of nerve agent-induced toxicity in rodents, and (4) performing kinetic studies to compare biochemical changes following different routes of exposure to nerve agents. Neurobehavioral assessments include measures of motor activity and function, cognitive performance, sensorimotor function, emotional memory, and measures of anxiety and depression. Telemetry is used to continuously measure EEG and evaluate seizures and alterations in circadian rhythms and will also be used to measure EKG and blood pressure. Molecular biology and histological techniques are used to evaluate neuropathology and mechanisms of toxicity.

 

References

Romano J, et al: Chemical warfare, chemical terrorism, and traumatic stress responses: An assessment of psychological impact, in Chemical Warfare agents: Chemistry, Pharmacology, Toxicology and Therapeutics. Edited by Romano JR, Lukey BJ, Salem H. CRC Press/Taylor and Francis Group, 2008

Whalley CE, et al: Toxicology 19(7): 667, 2007

 

Keywords:
Chemical warfare nerve agents; Behavior; Seizures; Anticonvulsants; Neuroprotection; Organophosphorus compounds; Hormones; Toxicokinetics; Toxicology; Social Stress; Animal models; Post-traumatic stress disorder;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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