AMRMC-U.S. Army Medical Research Institute of Infectious Diseases, US Army Medical Research Insti Infec Diseases
||Fort Detrick, MD 217025011
|Bozue, Joel A
We are interested in mechanisms of microbial pathogenesis with Yersinia pestis, Francisella tularensis, Bacillus anthracis, and the pathogenic Burkholderia spp (B. pseudomallei and B. mallei). The overall goal is to identify bacterial targets that these bacteria possess to identify novel vaccines or therapeutics. Ideally, a target for vaccination or a therapeutic would be necessary for virulence to avoid the natural selection or intentional manipulation of a resistant pathogen. Therefore, many of our laboratory projects involve the genetic construction of mutant strains in a gene encoding for the targeted protein. Virulence of the mutant strain is then assessed and compared to the parent strain through various in vitro and in vivo models of infection.
Additional studies in our laboratory focus on analyzing and characterizing mechanisms by which bacteria become resistant to antimicrobial compounds. By better understanding these mechanisms, approaches could be taken to identify methods to combat this problem.
Bozue J, et al: Phenotypic Characterization of a Novel Virulence-Factor Deletion Strain of Burkholderia mallei that Provides Partial Protection against Inhalational Glanders in Mice. Frontiers in Cellular and Infectious Microbiology 6(21), 2016
Bozue J, et al: A Yersinia pestis tat mutant is attenuated in bubonic and small-aerosol pneumonic challenge models of infection but not as attenuated by intranasal challenge. PLoS One 9(8): e104524, 2014
Dankova V, et al: Characterization of tetratricopeptide repeat-like proteins in Francisella tularensis and identification of a novel locus required for virulence. Infection and Immunity 82(12): 5347, 2014
Yersinia pestis; Francisella tularensis; Plague; Tularemia; Animal models; Burkholderia; Molecular biology; Infectious diseases; Bacterial pathogenesis;