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Opportunity at Chemical and Biological Defense Funded Laboratories (CBD)

Development of Vaccines and Therapeutics to Hemorrhagic Fever Viruses

Location

AMRMC-U.S. Army Medical Research Institute of Infectious Diseases, US Army Medical Research Insti Infec Diseases

RO# Location
01.10.01.B7513 Fort Detrick, MD 217025011

Advisers

Name E-mail Phone
Dye, John Michael john.m.dye1.civ@mail.mil 301.619.8782

Description

Opportunities are available for basic or applied research on emerging viral diseases with a particular emphasis on viruses causing hemorrhagic fever including Ebola virus and Marburg virus. The laboratory focuses on two fronts: filovirus vaccines and therapeutics. Current efforts focus on the development of filovirus vaccines (VLP and VRP) in NHP models and assessing the importance of immune interference generated by different vaccine candidates, evaluation of the potency of a vascular permeability inhibitor as a broad spectrum therapeutic, and generation of the only SEBOV specific monoclonal antibodies (patent) currently available for use. Lastly, the laboratory is on the forefront of research addressing the use of antibodies as a therapeutic for filovirus infection.

 

References

Dye, JM, et al: Proceedings of the National Academy of Sciences: December, 2011 (epub)

Carette JE, et al: Nature 477: 7364, 2011

Bradfute SB, Dye JM, Bavari S: Human Vaccines (7)6: 1, 2011

 

Keywords:
Filovirus; Ebola; Marburg; Vaccine; Therapeutic; Immunology; Antibody; Hemorrhagic;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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