Opportunity at Chemical and Biological Defense Funded Laboratories (CBD)
Molecular Diagnostics and Pathogenesis
AMRMC-U.S. Army Medical Research Institute of Infectious Diseases, US Army Medical Research Insti Infec Diseases
||Fort Detrick, MD 217025011
|Schoepp, Randal J.
Basic and applied research opportunities are available to study many aspects for the detection and identification of new and emerging pathogens and their applications to other fields of study. This program focuses on the use of modern molecular techniques for the development of rapid, sensitive, and specific assays to detect and identify viruses, bacteria, and toxins. Systems being developed involve many different platforms that detect nucleic acids, antigens, or antibodies. Studies can involve basic research or be more applied in nature. The Diagnostic Systems Division’s scope of research spans many different scientific disciplines, which offers an individual a wide variety of research opportunities. Developments in molecular diagnostics can be used as the basis for collaborations throughout the Institute to study molecular pathogenesis, host response to infection, gene expression, and antigenic and genetic variation. Current research efforts include the development of recombinant antigens and antibodies to improve or support current diagnostic assays. Prokaryotic, eukaryotic, and plant expression systems are being used in this work. Currently, there is significant effort in the development and characterization of single domain antibodies or nanobodies derived from camelids and sharks for use in diagnostic assays. Basic research needs to support these applied efforts include epitope identification and characterization of biological threat agents, development of cloning and expression systems for recombinant antibodies to include phage-display technology, cloning and sequencing, epitope mapping, gene shuffling, and high-frequency mutagenesis. The Institute provides high-level biocontainment facilities, expert personnel, state-of-the-art equipment, and up-to-date molecular tools to support scientific studies.
Molecular diagnostics; Molecular pathogenesis; Recombinant antibodies; Recombinant antigens; Single domain antibodies; Nanobodies;
Open to U.S. citizens
Open to Postdoctoral applicants