The National Academies Logo
Research Associateship Programs
Fellowships Office
Policy and Global Affairs

Participating Agencies - CBD

  Sign InPrintable View

Opportunity at Chemical and Biological Defense Funded Laboratories (CBD)

Peptide-Based Biosensors with Thin Silk Film Sensitivity and Stability Enhancement


NSRDEC-US Army Natick Soldier Research Center, Biotechnology

RO# Location
01.06.01.B8081 Natick, MA 017605020


Name E-mail Phone
Uzarski, Joshua Robert 508.233.4018


Natural antimicrobial peptides, as well as de novo designed sequences, have shown promise as semi-selective binding ligands for biosensor development for the detection and discrimination of pathogenic bacteria, endotoxins, and bacterial toxins such as Staphylococcal enterotoxin B (SEB). Silk fibroin protein, isolated from the Bombyx mori silk worm, has shown tremendous potential and utilization as a multifaceted functional material. Films of silk protein have shown the ability to stabilize active biomolecules and in some cases, enhance their activity. Furthermore, for optical sensing methods, thin silk films have provided enhanced analytical signals and lower limits of detection. We are exploring methods to incorporate bioactive peptides into thin silk fibroin films (10-100 nm) and investigating the potential stability and activity enhancement effects. The primary aims are to optimize ultrathin silk film formation on transductive substrates, optimize covalent incorporation of the peptides within and on the silk films, and to understand the expected stabilization and activity enhancement effects.


Biosensors; Bioconjugation; Antimicrobial peptides; Silk fibroin; SPR; Functional materials; Thin films; Chem/bio protection;


Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
Copyright © 2014. National Academy of Sciences. All rights reserved. 500 Fifth St. N.W., Washington, D.C. 20001.
Terms of Use and Privacy Statement.