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Opportunity at Chemical and Biological Defense Funded Laboratories (CBD)

Biomolecular Interactions of Nanoparticles


AFRL-711 Human Performance Wing, RHD/Bioeffects Division

RO# Location
01.01.02.B6373 Wright-Patterson AFB, OH 45433


Name E-mail Phone
Hussain, Saber M. 937.904.9517


Engineered nanomaterials, in the range of 1 to 100 nm in size, possess novel physical and chemical properties that can be used to create unique devices. Unique quantum properties of nanomaterials strongly influence their physicochemical properties, conferring electrical, optical, and magnetic properties not present in corresponding bulk materials with solid and crystal structures at a larger scale. Nanoscale materials show promise for military applications including reduced size and better performance of portable battlefield remote devices to monitor, control, and improve soldier’s mission performance.

Research focuses on investigating the interaction of nanoparticles with living cells including simple bacteria to eukaryotic cells with reference to their uptake, translocation, distribution, toxicity, and/or associated bio-effects. We are interested in understanding how these particles interact with cellular proteins and genes based on their physical and chemical properties (i.e., particle number, particle size, charge and shape, surface area of the primary particles).

This research will facilitate a better understanding of nanobio-interaction mechanisms, provide in-depth analyses of corresponding effects on biological systems, and enable the theoretical development of predictive bioresponse models. Such knowledge will not only help to improve nanomaterial safety strategies for the protection of both human and environmental health, but will also help to apply advanced nanobiotechnology to the development of future unique sensors.

An additional research focus is to understand molecular events occur while plasmonic Nanomaterials interface with nano-invasive electromagnetic field including but not limited to, radio-frequency and near infrared laser. The studies emphasize creation of unique structures with the ability to respond to an external, non-invasive electromagnetic field, when nanomaterials coupled with biomolecules (i.e., DNA or proteins) and their potential bioapplication as gene, protein, receptor regulators.


Nanoparticles; Nanomaterials; Nanotoxicity; Intracellular sensors; Cell Signaling; Remote activation; Nanodevices;


Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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